NAD+ Infusion: What It Is and What Research Shows So Far

In brief: An NAD+ infusion delivers the coenzyme NAD+ directly into a vein. NAD+ is found in every cell of the body and is involved in energy metabolism. Studies clearly describe that NAD+ levels decline with age. Whether an infusion changes this in the long term, and whether that brings any health benefit, has not yet been adequately studied in humans.

In this article we explain what is known, how an NAD+ infusion works and who should not have one.

What is NAD+?

NAD+ stands for nicotinamide adenine dinucleotide. It is a coenzyme, a helper molecule that many enzymes in the body need in order to work. NAD+ is involved in energy production in the mitochondria, in DNA repair processes and in a group of enzymes called sirtuins.

The body makes NAD+ itself, among other things from vitamin B3 (niacin) and other precursors in food. Healthy people with a balanced diet do not have an NAD+ deficiency in the classic sense.

Why NAD+ is discussed in connection with longevity

Several studies show that NAD+ levels in various tissues decrease with age. In cell and animal experiments, raising NAD+ levels sometimes had favourable effects on metabolism and ageing processes. These results cannot simply be transferred to humans.

That is why NAD+ is one of the most discussed topics in longevity research, and at the same time one where expectations and evidence are far apart. For a critical perspective, see our article NAD+ Infusions and the Longevity Hype.

What studies in humans show so far

There are only a few small studies on NAD+ infusions. A pilot study in healthy volunteers examined how NAD+ and its breakdown products change in the blood during an infusion lasting several hours. It shows that blood levels rise and that a slow infusion is better tolerated than a fast one.

There is somewhat more data on NAD+ precursors taken as capsules. These can also raise NAD+ levels in the blood. Whether this translates into measurable benefits for health, performance or life expectancy has not been proven; results from existing studies are mixed.

In practical terms: an NAD+ infusion is not an anti ageing cure and not a treatment for any disease. If you are interested, you should know that many promises online go beyond the current state of research. We discuss exactly this openly at your consultation.

Who an NAD+ infusion may be suitable for

An NAD+ infusion may be an option for adults who are interested in their long term health, have been medically assessed and understand the limited evidence. It does not replace a healthy lifestyle or care from your GP.

If you constantly feel exhausted or less resilient, the cause should be investigated first. Common culprits are iron deficiency, thyroid disease, low vitamin D or vitamin B12, poor sleep or other treatable causes. That is why every first infusion with us starts with a blood test.

How an NAD+ infusion works at our practice

1. Medical consultation and baseline bloods

We go through your medical history, your medication and any contraindications, and take a blood sample. On request we also measure your NAD+ level.

2. Individual composition

Only with your results do we decide together whether an NAD+ infusion makes sense for you, and set the dose and any additions, for example B vitamins or magnesium.

3. The infusion

The infusion runs slowly over several hours while you sit comfortably in our infusion lounge on the Fressgasse in central Frankfurt. We adjust the speed to how well you tolerate it; you can read, work or relax.

4. Observation

After the infusion you stay with us for about 15 minutes. In total, allow around three hours for the appointment.

How often is an NAD+ infusion given?

Online you will often find fixed protocols with several infusions per month. There is no scientific basis for such schedules. Whether and at what interval further infusions make sense is something we discuss with you after the first one, taking your tolerance into account.

Side effects and risks

During the infusion you may experience warmth, flushing, pressure in the chest or abdomen, nausea, headache or muscle cramps. These symptoms are usually related to the infusion speed and ease as soon as we slow down or pause briefly.

At the puncture site bruising or vein irritation is possible, rarely inflammation. Allergic reactions are very rare. That is why every infusion takes place under medical supervision.

An NAD+ infusion is not suitable during pregnancy and breastfeeding, with active cancer or ongoing cancer treatment, with severe heart, kidney or liver disease, or with known intolerances. We review your medication with you beforehand.

After the infusion most people can continue their day as normal. Drink enough fluids and avoid very strenuous exercise on the same day. If you feel dizzy, please do not drive yourself.

How much does an NAD+ infusion cost?

An NAD+ infusion is a self pay service and is billed according to the German medical fee schedule (GOÄ). The cost depends on the dose, the duration and the lab tests required. German statutory health insurance does not cover it, and private insurers usually do not either. You will receive the expected costs at your consultation before any treatment.

NAD+ infusion or capsules?

NAD+ precursors such as nicotinamide riboside are sold as dietary supplements. The same applies: blood levels can rise, but a health benefit has not been proven. If you take or plan to take such products, mention it at your consultation so we can take it into account alongside your results and medication.

Frequently asked questions about NAD+ infusions

How long does an NAD+ infusion take?

The infusion itself runs slowly over several hours. Including preparation and observation, allow around three hours.

Does an NAD+ infusion hurt?

What you mainly feel is the brief prick when the IV line is placed. During the infusion you may notice warmth or pressure; we then slow the rate down.

Can I work after the infusion?

In most cases, yes. Avoid very strenuous exercise on the same day, and please do not drive if you feel dizzy.

Can NAD+ levels be measured?

Yes, with a blood sample. There is no generally accepted reference range yet, so we always interpret the result together with your other findings.

Does health insurance cover the costs?

German statutory health insurance does not cover an NAD+ infusion, and private insurers usually do not reimburse it either.

Where can I get a physician supervised NAD+ infusion in Frankfurt?

At our practice on the Fressgasse in central Frankfurt, every infusion starts with a medical consultation and a blood test. Find out more on our page IV infusions in Frankfurt.

Conclusion

NAD+ is an important coenzyme and an exciting research topic. For infusions in humans, however, the evidence is still thin, and many promises online go further than the data. If you are interested, a medical consultation that looks at your blood results is the right first step. You may also like our article on vitamin C infusions.

Learn more about our IV infusions in Frankfurt and book a consultation